Cardiac Surgery, Cardiopulmonary Bypass, Lung
Conditions
Keywords
Endocan
Brief summary
Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.
Detailed description
The investigators will measure endocan levels in both pulmonary and systemic venous blood in patients undergoing on pump cardiac surgery. The main objective is to quantify the difference of endocan blood level between the pulmonary and the systemic circulation.
Interventions
None listed
Sponsors
Biothelis
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Planned on pump coronary artery bypass surgery * Non opposition
Exclusion criteria
* Age \< 18 years old * Emergent surgery * Valvular replacement surgery * Combined cardiac surgery * Patients with inflammatory, infectious or evolutive neoplastic pulmonary disease * Patients with valvular problems, in particular aortic insufficiency * Patients who refuse to participate * Legal inability or disability * Patients who will probably not cooperate for the study * Pregnancy and/or breast feeding * Patients not in the Social security system * Patients in the exclusion period of another study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass | At the end of cardiopulmonary bypass | Blood samples will be collected at the same time in both pulmonary and systemic circulation at the end of cardiopulmonary bypass to measure Endocan blood level. The primary outcome will be the absolute difference between the Endocan blod level in the pulmonary circulation and in the systemic circulation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Kinetic of Endocan blood level in the systemic circulation during on pump cardiac surgery | Prior to the start of cardiopulmonary bypass, at the beginning and at the end of cardiopulmonary bypass, and at the end of surgery | Blood samples will be collected in the systemic circulation prior to the start of cardiopulmonary bypass, at the beginning of the cardiopulmonary bypass and at the end of cardiopulmonary bypass, and at the end of the surgery |
Contacts
Primary ContactGuillaume Besch, MD
Outcome results
None listed