The Association of Gut Microbiota With Urinary Tract Infection in Infants

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04615689

Enrollment

Registered

2020-11-04

Start date

2021-12-01

Completion date

2023-12-01

Last updated

2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urinary Tract Infections

Brief summary

This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.

Detailed description

The investigators hypothesize that the gut environment reflected by intestinal microbiota influences the risk of urinary tract infection. This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants. The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2.

Interventions

OTHERThe collection of feces

When the infants will be diagnosed with urinary tract infection, feces will be collected. Feces will be collected from healthy infants with informed consent.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Months to 15 Months

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of febrile urinary tract infection. * Infants

Exclusion criteria

* Congenital kidney disease * Congenital heart disease * Other metabolic disease

Design outcomes

Primary

Measure	Time frame	Description
The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.	An average of 1 year, after the completion of recruitment.	The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2. From the OTU table, the investigators will conduct the differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection, using the linear discriminant analysis and analysis of differential abundance taking sample variation into account in R program and QIIME2.

Secondary

Measure	Time frame	Description
The differential functional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.	An average of 1 year, after the completion of recruitment.	The investigators will predict the functional analysis from the OTU table and compare those results between healthy controls and infants with febrile urinary tract infection, using PICRUST2 analysis.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026