Normal Subject, Patient With Pharmaco-resistant Epilepsy
Conditions
Keywords
MEG, OPM, epilepsy, normal brain activity
Brief summary
Our goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography sensors (OPM He4) to record brain magnetic activities. The investigator will record 1) normal subjects stimulated with visual, auditory, somesthesic and motor stimuli and 2) epileptic patient. The investigator will compare the signal to noise ratio of the normal or pathological activities between classical MEG sensors and our OPM He4 prototype.
Interventions
DEVICEMEG recordings
1. Classical MEG recordings (patient at rest, normal subjects stimulated with visual, motor, somesthesic and auditory stimuli). 2. MEG recordings with our OPM He4 prototype (patient at rest, normal subjects stimulated with visual, motor, somesthesic and auditory stimuli).
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Volunteers: * Age 18+ * Right handed * Medical insurance * Strongly motivated to participate to the study * Signed informed consent for the study * No previous neurology or psychiatric pathologies * No major cognitive deficit and able to understand the instructions Patients: * Age 18+ * Right handed * Medical insurance * Strongly motivated to participate to the study * Signed informed consent for the study * No previous neurology or psychiatric pathologies (except epilepsy) * Epilepsy evolving during at least two years * No major cognitive deficit and able to understand the instructions
Exclusion criteria
Volunteers: * Age \< 18 years or \> 60 * previous neurology or psychiatric pathologies * Child bearing women * Subject having one of the following mettalic parts : * (pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve) * Claustrophobia Woman with a positive pregnancy test during the inclusion. Patients: Age \< 18 years or \> 60 * previous neurology or psychiatric pathologies except epilepsy * Child bearing women * Subject having one of the following mettalic parts : * (pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve) * Claustrophobia Woman with a positive pregnancy test during the inclusion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Signal to Noise Ratio of the recorded brain activities | 1 month | Volunteers: The signal to noise ratio of normal brain activity following a stimulus will be computed with respect to the pre-stimulus baseline -100ms to -10 ms. Epileptic patient: The signal to noise ratio of abnormal epileptic brain activity will be computed with respect to a 100 ms baseline not containing any abnormal activity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Signal to Noise Ratio of pre-frontal auditory activity | one month | evaluate the capacities of MPO to record pre-frontal auditory activities which are not recorded by classical MEG. EEG will be the reference |
| Signal to Noise Ratio of high frequency epileptic activity | one month. | evaluate the capacities of our MPO to record high frequency epileptic signal which are not recorded by current generation of MPO |
| Comfort of the subject during the MPO He4 recordings for epileptic patient through a short verbal questionary | 5 minutes after the end the recording session | The evaluation will be done verbally through a short questionary. This questionary evaluates the overall comfort of the MPO system with two questions: 1) An evaluation of the overall comfort thanks to a scale with five steps from very uncomfortable to very comfortable and 2) A comparison with the classical MEG system thanks to a 5 steps scale from much less comfortable than the classical MEG system to much more comfortable. |
| Comfort of the subject during the MPO He4 recordings for volunteers through a short verbal questionary | 5 minutes after the end of each recording session | The evaluation will be done verbally through a short questionary. This questionary evaluates the overall comfort of the MPO system with two questions: 1) An evaluation of the overall comfort thanks to a scale with five steps from very uncomfortable to very comfortable and 2) A comparison with the classical MEG system thanks to a 5 steps scale from much less comfortable than the classical MEG system to much more comfortable. |
Countries
France
Contacts
Primary ContactJulien JUNG, MD
Backup ContactDenis SCHWARTZ, MD
Outcome results
None listed