Lung Cancer Risk and Early Detection in Firefighters

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04614129

Enrollment

734

Registered

2020-11-03

Start date

2021-03-02

Completion date

2025-11-01

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer, Lung Diseases

Brief summary

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Interventions

DIAGNOSTIC_TESTLow Dose CT

All participants will have a low dose chest CT either within one year of enrollment or after enrollment

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* 40-80 years of age or with 10 years of firefighting experience * Current or retired firefighters * No personal history of lung cancer * Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study

Exclusion criteria

* Any active cancer (undergoing treatment or diagnosed within the past 5 years)

Design outcomes

Primary

Measure	Time frame	Description
Nodule detection rate	12 months	Frequency of nodule detection
High-risk nodule detection rate	12 months	Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious

Secondary

Measure	Time frame	Description
Interstitial lung disease detection rate	12 months	Frequency of interstitial lung disease detection
Coronary artery calcification (CAC) ordinal scores	12 months	Frequency of high coronary artery calcification (CAC) ordinal scores. Possible scores range from 0 to 12 and high scores are defined as those greater than or equal to 10

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026