Electronic Cigarette Use
Conditions
Keywords
E-cigarette, Autonomic Control, Muscle Sympathetic Nerve Activity
Brief summary
E-cigarettes are marketed as an alternative to smoking for those who want to decrease the health risks of tobacco. Tobacco cigarettes increase heart rate (HR) and arterial pressure, while reducing muscle sympathetic nerve activity (MSNA) through sympathetic baroreflex inhibition. The acute effects of e-cigarettes on arterial pressure and MSNA have not been reported: our purpose was to clarify this issue. Using a randomized crossover design, participants inhaled on a JUUL containing nicotine (59 mg/ml) and a similar placebo e-cigarette (0 mg/ml).
Interventions
DEVICEElectronic Cigarette containing nicotine
Non-smokers used an electronic cigarette containing nicotine
Non-smokers used an electronic cigarette without nicotine
Sponsors
Michigan Technological University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Participants were not informed if they were to receive nicotine or placebo
Intervention model description
Repeated Measures
Eligibility
Sex/Gender
ALL
Age
21 Years to 40 Years
Healthy volunteers
Yes
Exclusion criteria
* Individuals with a history of hyperthyroidism * Women currently taking oral contraceptives, are pregnant or breast-feeding, or trying to become pregnant * Individuals currently taking prescription drugs. * Individuals with respiratory illnesses (e.g., asthma, chronic obstructive pulmonary disease, reactive airway disease, etc.) * Individuals with hypertension (systolic \>130 and/or diastolic \> 80). * Individuals with a history of tobacco or vaporized nicotine use. * Individuals who have been diagnosed with diabetes * Individuals who are under the age of 18 or over the age of 40
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure (measured from the finger) | Experiments were separated by one month. Beat-to-beat arterial pressure was recorded for ten minutes at rest, during ten minutes of e-cigarette use, and for ten minutes during recovery. The last 5 minutes of each section were averaged. | Effects of electronic cigarettes on both systolic and diastolic arterial pressure. |
| Muscle sympathetic nerve activity (measured with the microneurography technique) | Experiments were separated by one month. MSNA was recorded for ten minutes at rest, during ten minutes of e-cigarette use, and for ten minutes during recovery. The last 5 minutes of each section were averaged. | Effects of electronic cigarettes on muscle sympathetic nerve activity (MSNA) |
Countries
United States
Outcome results
None listed