Hemorrhagic Stroke, Ischemic Stroke, Stroke
Conditions
Keywords
blood biomarkers, stroke diagnosis, stroke, biomarkers, reperfusion therapies, acute stroke therapy, prehospital stroke management
Brief summary
Stroke is the first cause of death among Spanish women and main cause of disability. Reperfusion therapies of the occluded artery remain the only useful approach in acute ischemic stroke. However, the efficacy of these strategies is highly time-dependent and due to the need of neuroimaging (CT or MRI) to differentiate between ischemic and hemorrhagic stroke, impossible to be performed at the pre-hospital level. The investigators aim to set-up a point of-care (POC) device to validate a biomarker panel differentiating ischemic and hemorrhagic stroke at the pre-hospital level using a blood sample and to validate a second biomarker panel for the early identification of patients with large vessel occlusions (LVO), which are candidates for mechanical thrombectomy. For that, the investigators will recruit a 300 patients' cohort with pre-hospital blood samples using available POCs for each of those markers.
Interventions
None listed
Sponsors
Hospitales Universitarios Virgen del Rocío
Hospital Alta Resolución Sierra Norte
Hospital San Juan de Dios Aljarafe
Hospital Universitario Reina Sofia de Cordoba
Hospital Universitario Virgen Macarena
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* I.1: Patients \> 18 years old. * I.2: Stroke code activated by the coordinator centre. * I.3: \< 6 hours from symptoms onset. In the case of stroke with uncertain chronology or wake-up stroke, the initial time will be considered as the last moment the patient was seen fine.
Exclusion criteria
* E.1: Prehospital diagnosis different of stroke. * E.2: Impossibility of getting a prehospital blood sample. * E.3: Refusal to provide the informed consent by the patient/relative.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stroke subtype diagnostic accuracy | through study completion, an average of 2 years | Stroke subtype diagnostic (% ischemic versus % hemorrhagic and % stroke mimics) will be determined by clinical and neuroimaging criteria at hospital arrival and compared with diagnostic accuracy of a blood biomarkers based test |
| Reperfusion rates | through study completion, an average of 2 years | — |
| Times to reperfusion | through study completion, an average of 2 years | — |
Countries
Spain
Outcome results
None listed