Anxiety, Cognitive Dysfunction, Depression, Fatigue, Pain, Sleep Disturbance, Survivorship
Conditions
Keywords
Breast Cancer and Colorectal Cancer, Co-Occurring Symptoms
Brief summary
This descriptive, cross-sectional study will evaulate and fully characterize factors associated with cognitive dysfunction in Breast Cancer (BCS) and Colorectal Cancer (CRC) survivors that have cognitive concerns, and factors associated with psychoneurological symptom cluster in BCS and CRC survivors.
Detailed description
Primary Aim: To identify demographic factors (age and education), medical and cancer treatment-related factors (comorbidities and treatment type), psychosocial factors (perceived stress, affect, optimism, coping, emotional support), cancer-related symptoms (pain, depression, anxiety, fatigue and sleep disturbance), and genetic factors (APOE, COMT, BDNF) associated with the level of subjective or the level of objective cognitive dysfunction in breast cancer and colorectal cancer survivors. Secondary Aim: To identify demographic factors (age and education), medical and cancer treatment-related factors (comorbidities and treatment type), psychosocial factors (perceived stress, affect, optimism, coping, emotional support), and genetic factors (APOE, COMT, BDNF) associated with psychoneurological symptom cluster using either subjective or objective cognitive dysfunction in breast cancer and colorectal cancer survivors.
Interventions
BEHAVIORALCognitive Dysfunction
To fully characterize factors associated with cognitive dysfunction in BCS and CRC survivors that have cognitive concerns and (2) to fully characterize factors associated with psychoneurological symptom cluster in BCS and CRC survivors.
Sponsors
Indiana University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Inclusion Criteria for Breast cancer survivors: 1. Female BCS 2. ≥ 21 years of age and older 3. Ability to provide written consent and HIPAA authorization 4. ≥6 months post-adjuvant therapy and neo-adjuvant therapy for early stage (Stage I-IIIA) breast cancer. Current Aromatase Inhibitors or Tamoxifen treatment at time of enrollment is allowed. 5. Identify cognitive concerns (select yes) Inclusion Criteria for Colorectal cancer survivors: 1. Male or female CRC survivors 2. Ability to provide written consent and HIPAA authorization 3. ≥ 21 years of age and older 4. ≥6 months post-adjuvant therapy and neo-adjuvant therapy for early stage (stage I-III) CRC 5. Identify cognitive concerns (select yes)
Exclusion criteria
1. Report metastatic breast or colorectal cancer (Stage IV) at time of consenting. 2. Unable to read and understand English to complete survey questionnaires.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Cognitive Dysfunction | greater than or equal to 6 months post cancer treatment | PROMIS - Cognitive Abilities and Concerns |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Objective Cognitive Dysfunction | greater than or equal to 6 months post cancer treatment | Visual Episodic Memory |
Countries
United States
Outcome results
None listed