Inflammation Function, Postoperative Pain, Postoperative Sleep Quality, Sex Differences
Conditions
Keywords
sex differences, postoperative sleep quality, postoperative pain, inflammation function
Brief summary
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. And sleep disruption also remains a challenging problem in surgical settings. Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patient's physical condition. The aim of the study was to investigate the effect of sex differences on postoperative pain, inflammation and sleep quality among patients who have undergone video-assisted thoracoscopic surgery under general anesthesia.
Interventions
OTHERVideo-Assisted Thoracoscopic Surgery
patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia
Sponsors
Shengjing Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* 18-80 years old * ASA I-III * under general anesthesia
Exclusion criteria
* patients with central nervous system and mental diseases; * patients with preoperative sleep disturbances; * patients with a history of sedative, analgesic, or antidepression drug use; * patients with sleep apnea or moderate and severe obstructive sleep apnea-hypopnea syndrome;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sleep quality of one night before surgery | first night before surgery | Use Athens insomnia scale to test the sleep quality the first night before surgery |
| sleep quality of first night after surgery | first night after surgery | Use Athens insomnia scale to test the sleep quality the first night after surgery |
| sleep quality of third night after surgery | third night after surgery | Use Athens insomnia scale to test the sleep quality the third night after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| visual analog scale(VAS) score after surgery | one day before surgery | evaluate VAS score after surgery |
| Postoperative cognition evaluation | one day before surgery | Use MMSE Mini-Mental State Examination (MMSE) was also evaluated at Sleep preop 1, Sleep POD 1 and Sleep POD 3.18 Each correct answer is 1 point, and error or unknown is 0 point. The unsuitable one is 9 points, and refusing to answer or incomprehension is 8 points. In the total score, 8 points and 9 points are calculated by 0 points. The highest score is 30 points. The division of dementia or not is related to the degree of education. The dementia is affirmed by the patient who is illiterate and less than 17 points, the primary school is less than 20 points, and more than middle school is less than 24 points. The scores which from 27 to 30 is normal, 21 to 26 of mild, 10 to 20 of moderate, and from 0 to 9 is severe. |
| postoperative adverse effect | 24 hours after surgery | evaluate postoperative adverse effect 24 hours after surgery |
| perioperative inflammation function | two days before surgery | evaluate neutrophils |
Countries
China
Outcome results
None listed