Preterm Infant, Renal Failure
Conditions
Brief summary
From the first days of life, the newborn presents a physiological proteinuria explained by the coexistence of a glomerular and tubular immaturity, all the more marked as the gestational age (GA) is weak. In the child term, proteinuria decreases the first month and its persistence is the marker of kidney damage. The persistence of proteinuria in preterm infants is also considered a marker of renal impairment; however, neither the physiological values nor the pattern of urinary excretion of proteins in the first month of life are known. The proteinuria / creatininuria ratio is a validated indicator of proteinuria, as it is correlated with 24-hour urine proteinuria.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire de la Réunion
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 2 Days
Healthy volunteers
No
Inclusion criteria
* Premature gestational age at birth superior or equal to 32 week of amenorrhea hospitalized in the intensive care unit or neonatal intensive care unit of the University Hospital of Reunion, southern site, Saint Pierre, in the first 24 hours of life * Informed consent form Legal representant
Exclusion criteria
* Renal malformation known in antenatal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evolution in time of Ratio of proteinuria / creatininuria | Day 0, Day 2 or Day 3, Day 5 or Day 6, Week 2, Week 3, Week 4 | Ratio of proteinuria / creatinine to P1 (D0), P2 (D2 or D3), P3 (D5 or D6), P4 (W2), P5 (W3) and P6 (W4). |
Countries
France
Outcome results
None listed