Cerebrovascular Accident
Conditions
Brief summary
The aim of this study is to investigate lower limb muscles after cerebrovascular accident
Detailed description
The aim of this study is to define and differentiate the changes in MMT properties related to the alterations in muscle tone of the lower limb in first-ever chronic stroke patients by using a 3D free-hand Ultrasonography (3DfUS) technique in combination with an instrumented spasticity assessment (IPSA). In these chronic stroke patients, the spontaneous neurological recovery is stabilized
Interventions
DIAGNOSTIC_TEST3DfUS and IPSA of leg muscles
1. 3DfUS technique enhances a conventional 2D US device into a platform capable of reconstructing 3D anatomical data sets. 2. IPSA for quantification of hyper-resistance and its underlying components. The sensors in the IPSa include gyroscopes and accelerometers to measure joint angle and angular velocity, EMG to measure muscle activity, and a 3 degrees-of freedom force sensor to measure torque applied on the joint. 3. clinical functional capacity = clinical evaluation of degree of independence, mobility and gait
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Definition of case population : o first ever stroke with spasticity of the lower limb. * Definition of control : * first ever stroke without spasticity of the lower limb * healthy aged-matched subjects
Exclusion criteria
* Musculoskeletal or neurological problems affecting the lower limb * Presence of other neurological pathology that could lead to spasticity, ataxia, dystonia * Cognitive problems that impede measurements * Severe co-morbidities * Peripheral spastic medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intensity of catch derived from the fast stretch | 1 day | Measurement of Intensity of catch by Instrumented Spasticity Assessment |
| Muscle and Tendon Length | 1 day | Estimation of muscle volume by 3D freehand ultrasonography |
| Echogenicity intensity | 1 day | Estimation of echogenicity intensity by 3D freehand ultrasonography on an 8-bit greyscale (256 values). |
| Work [J] derived from the slow stretch | 1 day | Measurement of Work \[J\] by Instrumented Spasticity Assessment |
| Muscle activity EMG [uV] derived from the fast stretch | 1 day | Measurement of Muscle activity EMG \[uV\] by Instrumented Spasticity Assessment |
| Maximal velocity of performance (Vmax [deg/s]) | 1 day | Measurement of Maximal velocity of performance (Vmax \[deg/s\]) by Instrumented Spasticity Assessment |
| Range of motion [deg] for slow stretch | 1 day | Measurement of Range of motion \[deg\] by Instrumented Spasticity Assessment |
| Stiffness [Nm/deg] for slow stretch | 1 day | Measurement of Stiffness \[Nm/deg\] by Instrumented Spasticity Assessment |
| Joint angle of catch [deg] from the fast stretch | 1 day | Measurement of Joint angle of catch \[deg\] from the fast stretch by Instrumented Spasticity Assessment |
| Angle of EMG threshold [deg] from the fast stretch | 1 day | Measurement of Angle of EMG threshold \[deg\] by Instrumented Spasticity Assessment |
| Muscle volume | 1 day | Estimation of muscle volume by 3D freehand ultrasonography. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical assessment of spasticity angle at slow and fast stretch | 1 day | Estimation of spasticity by Tardieu Scale |
| Clinical assessment of spasticity at fast stretch | 1 day | Estimation of spasticity by Modified Assessment Scale |
Other
| Measure | Time frame | Description |
|---|---|---|
| Assessesment of mobility in stroke patients | 1 day | Evaluation of mobility after stroke is assessed by the Rivermead Mobility Index |
| Assessment of transfer skills in stroke patients and healthy subjects | 1 day | Measurement of functional lower extremity strength and/or identify movement strategies in stroke patients and healthy subjects by The Five Times Sit to Stand Test |
| Assessment of the motor impairment in lower limbs of stroke patients | 1 day | Measurement of lower limb strength in stroke patients by the Motricity Index |
| Assessments of gait speed analysis in stroke patients and healthy subjects. | Measurement of gait speed in stroke patients and healthy subjects by 5-Meter Walk Test at comfortable or self-selected gait speed. | 1 day |
| Assessments of functional independence in daily life in stroke patients and healthy subjects | 1 day | Evaluation of functional independence in daily life is assessed by the Barthel Index |
| Quantify the impairment caused by a stroke | 1 day | Evaluation of impairment caused by stroke by National Institute Health Stroke Scale |
| Assessments of functional status after stroke | 1 day | Evaluation of functional status after stroke is assessed by the Functional Independence Measure |
Countries
Belgium
Outcome results
None listed