Non-ischemic Cardiomyopathy
Conditions
Keywords
LGE MRI, Ventricular tachycardia, sudden cardiac death, non-ischemic cardiomyopathy
Brief summary
Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related. While electrophysiological mechanisms underlying ventricular arrhythmia are well known, late gadolinium enhanced (LGE) cardiac MRI-3D reconstructions are now able to guide VT ablation procedures. Such exam may help in identifying specific properties of scar at risk of malignant arrhythmia.
Interventions
DIAGNOSTIC_TESTCardiac MRI
Comparison of scar characteristics on cardiac MRI between the two groups.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Adult with NICM * Previous history of ventricular tachycardia (VT) and no previous history of VT
Exclusion criteria
* Inherited cardiomyopathies * Previous history of myocarditis WITHOUT oedema/scar at the MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detect pro arrhythmogenic scar characteristics | baseline : collected at the time of the cardiac MRI | The outcomes will aim to provide scar characteristics from 3D cardiac MRI reconstructions to detect pro arrhythmic properties in NICM patients. Comparisons between NICM patients who experienced VT ablation and NICM patients without history of ventricular arrhythmia will be made. In both groups, Primary outcome will aim to measure the number of the conducting channels into scars (n). |
Outcome results
None listed