Ischemic Strokes While on NOAC - How Compliance Matters

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04607070

Enrollment

Registered

2020-10-28

Start date

2020-10-01

Completion date

2025-06-30

Last updated

2026-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis, Ischemic Stroke, Stroke, Acute, Stroke, Cardiovascular, Stroke, Ischemic, Stroke Syndrome

Keywords

stroke, NOAC

Brief summary

This study is aimed to depict the epidemiological trend, aetiologies, clinical characteristics, treatment options of IS-NOAC in face of the rapidly increasing NOAC usage. Knowledge on this ischaemic stroke entity will define clinical characteristics, identify preventable causes and inform resource allocation on the evaluation modalities, reperfusion strategies and forecast future burden of IS-NOAC.

Detailed description

Data will be retrieved from the stroke registry of Prince of Wales Hospital which recorded all in- and out-patients with stroke or transient ischaemic attack (TIA). All consecutive adult patients with known AF who developed ischaemic stroke or TIA in 2010, 2012, 2014, 2016 and 2018 (i.e. 5 full yearly time-points) and categorize the patients according to their anticoagulation status (elaborated below) with the inclusion and exclusion criteria stated will be recruited. All demographic data, blood results, imaging and assessment data will be retrieved from electronic patient record (CMS system) and stroke registry. All-cause mortality at 1 year will be verified via CMS system too.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients who were ethnic Chinese 2. Patients with known AF 3. Patient who suffered from ischaemic stroke

Exclusion criteria

1. Patient who are non-ethnic Chinese 2. Patient who suffered from haemorrhagic stroke

Design outcomes

Primary

Measure	Time frame	Description
Compliance affects the outcomes of ischemic stroke during NOAC usage.	30 Sept 2021	To depict epidemiological trend and aetiologies on different dosage of NOAC in stroke patients.

Countries

Hong Kong

Contacts

PRINCIPAL_INVESTIGATORYiu Ming Bonaventure IP, MBChB, MRCP

Chinese University of Hong Kong

Outcome results