Fertility Disorders
Conditions
Brief summary
Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.
Detailed description
Two hundred females with history of recurrent implantation failure and undergoing Intracytoplasmic Sprem injection (ICSI) were randomized into two groups; the first group (100 patients) received intrauterine Granulocyte colony stimulating factor (GCSF) and the second group (100) received intrauterine Human Chorionic Gonadotropin (HCG) at ovum pick up day. The clinical pregnancy rate was evaluated as a primary outcome after 14 days and ultrasound imaging of gestational sac was evaluated as a secondary outcome after 6 weeks.
Interventions
GCSF was intrauterine injected once at ovum pick up day
500 IU of HCG was injected intrauterine once at ovum pick up day
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Females suffering from recurrent implantation failure and undergoing ICSI
Exclusion criteria
* presence of comorbidity as diabetes, hypertension, heart diseases, or endocrine disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | after 14 days from positive pregnancy test | Clinical pregnancy was evaluated by high HCG levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gestational sac imaging | 6 weeks of pregnancy | ultrasound imaging of Gestational sac after 6 weeks of pregnancy |
Contacts
Primary ContactElsayed Eldesouky
Outcome results
None listed