Paraganglioma, Pheochromocytoma
Conditions
Keywords
pheochomocytoma, brown adipose tissue, infrared thermography, cutaneous microcirculation, PET-CT
Brief summary
Patients affected by pheochromocytoma (PHEO) have brown-adipose tissue (BAT) hyperactivation. They perform, in routine settings, a FDG PET-CT scan. The high metabolic activity of BAT and its ability to consume both glucose and fatty acid suggest that it may have potential as a therapeutic target in the treatment of obesity. However, alternative non-invasive techniques to PET-CT BAT detection still need more validation. Accordingly, our aim will be to measure the temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test in PHEO patients.
Detailed description
Objectives and Methodology: * To analyse the change in temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test in PHEO patients. * To check the decreased temperature and microcirculatory response after a cold test following resection of the tumor All the patients affected by will benefit from a: * clinical: treatments * biological evaluations: glycemia, triglycerides, total cholesterol, HDL-C, LDL-C, plasma epinephrine and norepinephrine, urine catecholamine * cutaneous microcirculation by means of Laser Speckle Imaging will be recorded at rest and during a cold test in the supra-clavicular region * cutaneous microcirculation by means of Laser Doppler Flowmetry will be recorded at rest and during a cold test with one probe in the supra-clavicular region and one probe in umbilical region * skin temperature by means of infrared thermography will be recorded at rest and during a cold test in the supra-clavicular region Patients who will have surgery will be investigated before and after one year following resection of the tumor.
Interventions
DIAGNOSTIC_TESTInfrared themrography
measurement of temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test
Sponsors
Centre Hospitalier Henri Duffaut - Avignon
Assistance Publique Hopitaux De Marseille
University of Avignon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with confirmed pheochromocytoma and/or paraganglioma
Exclusion criteria
* pregnant woman * breastfeeding woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin temperature in supra-clavicular region in basal condition (TSCRbasal) | Day 0 | Skin temperature in supra-clavicular region will be recorded by infrared thermography (FLIR camera) in basal condition |
| Skin temperature in supra-clavicular region during a cold test (TSCRcold) | Day 0 | Skin temperature in supra-clavicular region will be recorded by infrared thermography (FLIR camera) during a cold test (feet in water at 19°C during 20min) |
| Baseline difference in skin temperature in supra-clavicular region (diff TSCR) | Day 0 | diff TSCR (day 0) = TSCRcold - TSCRbasal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Volume of Brown Adipose Tissue detected by PET-CT | Day 0 | 18FDG PET-CT will be performed and volume will be segmented by PET/CT Viewer.. |
| Activity of Brown Adipose Tissue detected by PET-CT | Day 0 | 18FDG PET-CT will be performed and BAT activity (Standardized Uptake Value (SUV) will be segmented by PET/CT Viewer.. |
| Cutaneous blood flow in supra-clavicular region in basal condition (PUbasal) | Day 0 | Cutaneous blood flow in supra-clavicular region will be recorded by Laser Speckle Imaging (PeriCam) in basal condition |
| Change from baseline difference in cutaneous blood flow in supra-clavicular region ( ∆ diff PU) at 12 months | Month 12 | ∆ diff PU = diff PU (month12) - diff PU (day0) |
| Change from baseline difference in skin temperature in supra-clavicular region ( ∆ diffTSCR) at 12 months | Month 12 | ∆ diff TSCR = diff TSCR(month12) - diff TSCR (day0) |
| Cutaneous blood flow in supra-clavicular region during a cold test (PUcold) | Day 0 | Cutaneous blood flow in supra-clavicular region will be recorded by Laser Speckle Imaging (PeriCam) during a cold test (feet in water at 19°C during 20min) |
| Baseline difference in cutaneous blood flow in supra-clavicular region (∆PU) | Day 0 | diff PU (day0) =PUcold-PUbasal |
Countries
France
Outcome results
None listed