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The Consistency of Cardiac Output Measured by Pulmonary Artery Catheter and LiDCO in Cardiac Surgical Patients

The Consistency of Cardiac Output Measured by Pulmonary Artery Catheter and LiDCO in Cardiac Surgical Patients

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04604886
Enrollment
40
Registered
2020-10-27
Start date
2020-09-30
Completion date
2024-06-30
Last updated
2020-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery, Cardiac Output

Keywords

Hemodynamic Monitoring, Pulmonary artery catherization, LiDCO

Brief summary

1. To evaluate the consistency of cardiac output measured by pulmonary artery catheter and LiDCO in cardiac surgical patients 2. To evaluate whether different hemodynamic monitoring methods can accurately detect the trend of cardiac output changes

Detailed description

Close monitoring of cardiac output (CO), especially in patients before and after intervention(such as volume expansion, diuresis, vasoconstriction, vasodilation therapy), could help to adjust the treatment strategy in cardiac surgical patients. Pulmonary artery catherization (PAC) has been used for hemodynamic monitoring for more than four decades. In spite of its invasiveness, it remains the clinical reference method for the assessment of CO at the bedside. Nowadays, many less invasive alternatives, such as LiDCO Rapid Pulse Contour Analysis System (LiDCO Ltd., Cambridge, United Kingdom), are already available on market. However, consistency between different hemodynamic monitoring results still raise concern. And whether hemodynamic monitoring could accurately detect the changes of these parameters before and after intervention is an important issue in clinical practice. In this study, the investigators are going to collect CO and changes of CO from PAC and LiDCO before and after intervention (passive leg raising and dobutamine stress test) in cardiac surgical patients. Our resulst could provide important reference for cardiac surgical patients how to choose appropriate hemodynamic monitoring tools and how to interpret the results of hemodynamic monitoring.

Interventions

DIAGNOSTIC_TESTPassive Leg Raising

Passive leg raising is induced by rasing the legs of patients to 45° from horizontal position.

DIAGNOSTIC_TESTDobutamine stress test

Dobutamine was infused intravenously at the initial dose of 2.5 ug/kg/min. hemodynamic data were recorded from PAC and LiDCO after 5-10 minutes of continuous infusion.

Sponsors

Shanghai Zhongshan Hospital
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

1. cardiac surgery 2. hemodynamic monitoring (PAC, LiDCO) 3. mechanical ventilation

Exclusion criteria

1. cardiac arrhythmia 2. moderate to severe aortic, mitral and tricuspid regurgitation 3. IABP 4. ECMO

Design outcomes

Primary

MeasureTime frameDescription
Baseline Cardiac Output measurementwithin1 minute at baseline positionCardiac Output measured at baseline position (horizontal position)
Cardiac Output measurement after PLR1 minute after PLRCardiac Output measured after PLR
Cardiac Output measurement after Dobutamine stress test5 minutes after dobutamine stress testCardiac Output measured after dobutamine stress test

Countries

China

Contacts

Primary ContactGuo-wei Tu, Doctor
tu.guowei@zs-hospital.sh.cn86-021-64041990
Backup ContactYijie Zhang, Doctor
zhang.yijie@zs-hospital.sh.cn86-021-64041990

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026