COPD
Conditions
Keywords
COPD,, Pulmonary rehabilitation,, Airway immunity
Brief summary
The purpose of this study is to determine whether whole body exercise training alters the immunity in the lungs of people with COPD and reduces the incidence of chest infections over the longer term.
Detailed description
Patients will undertake an 8 weeks pulmonary rehabilitation program of exercise and education. Those who decline to take part in pulmonary rehabilitation will have the same outcome measures collected at the same timepoints.
Interventions
OTHERPulmonary rehabilitation
8 weeks of exercise training (twice weekly) of education and exercise
Sponsors
Austin Health
Newcastle University
Bayside Health
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of COPD (FEV1/FVC \< 70), smoking Hx of minimum of 10 pack years
Exclusion criteria
* Diagnosis of asthma, bronchiectasis, attendance at pulmonary rehabilitation within last 12 months, exacerbation of COPD within last 4 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Salivary Immunoglobulin A levels | Change over 8 weeks | SIgA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in circulatory inflammatory markers | Change over 8 weeks | — |
| Change in physical activity levels | Change over 8 weeks | — |
| Health status | Change over 8 weeks | COPD assessment test |
| Exercise capacity (6MWT) | Change over 8 weeks | Distance walked in 6 minutes |
| Number of acute exacerbations | 12 months | — |
Countries
Australia
Outcome results
None listed