Allergic Rhinitis
Conditions
Brief summary
The investigators aimed to explore miRNA-155 change in response to sublingual immunotherapy (SLIT), probiotics and combined treatment with SLIT and probiotics in AR children.
Detailed description
Allergic rhinitis (AR) is an inflammatory state characterized by a disturbance of immunoregulatory mechanisms that leads to an amplified T helper Th-2 response. Micro-RNAs (miRNAs) are short single-stranded RNA molecules that post transcriptionally control gene expression and can mediate allergic process. The aim of this study was to explore miRNA-155 change in response to sublingual immunotherapy (SLIT), probiotics and combined treatment with SLIT and probiotics in AR children.
Interventions
DRUGLacteol fort
Lacteol fort is a drug containing lactobacilli
DRUGStandardized Timothy Grass Pollen
SLIT includes 2 phases build up and maintenance phases. (Jubilant HollisterStier LLC 14110 Collections Drive, Chicago USA) .
DRUGLacteol fort and Standardized Timothy Grass Pollen
Lacteol fort is a drug containing lactobacilli and the Standardized Timothy Grass Pollen includes 2 phases build up and maintenance phases.
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Group I included 15 cases who received probiotics only. Group II included 15 children who received SLIT. Group III included 15 children who received probiotics and SLIT.
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 5-18 years * Diagnosed as having AR * With positive skin test to grass pollen
Exclusion criteria
* Anatomical abnormalities of upper respiratory tract, * Previous immunotherapy, * Clinically significant inflammatory diseases, * Malignancies, * Chronic treatment with systemic corticosteroids or immune suppressive drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total nasal symptom score between before and after treatment | 6 months | Total Nasal Symptom Score was evaluated for the three groups at the start of the study and after 6 months. TNSS is the sum of scores for each of nasal obstruction, sneezing, nasal itching, and rhinorrhea at each time point, by means of a four-point scale (0-3) . TNSS is estimated by addition of the score for each of the symptoms to a total out of 12 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum miR-155 expression at the start and end of the study | 6 months | Serum miR-155 expression was measured for the three groups by quantitative real time PCR |
Countries
Egypt
Outcome results
None listed