Infertility
Conditions
Keywords
fertility preservation, fertility treatment, safety, efficacy, fertility outcomes, follow-up, cohort
Brief summary
This study analyses clinical data prospectively collected for over a decade in several clinical databases. Electronic medical records are available since 1998. Since 2011 the subgroup of patients that undergo fertility preservation are invited to participate in a prospective study aiming at long-term follow-up after fertility preservation for oncologic and non-oncologic conditions.
Detailed description
In this study, the investigators aim at analyze the treatment outcomes of patients with infertility, their clinical characteristics and biochemical parameters aiming at identifying predictors for the treatment outcomes. For the cohort of patients that have undergone fertility preservation at Karolinska University Hospital, the investigators aim at investigating efficacy and safety of the procedures. The data can be expanded by using additional databases such as the Regional Cancer Registry and other registries. Analysis of data collected will allow the investigation of efficacy and safety of fertility preservation, identification of predictors for fertility outcomes,prediction of future activities and costs of the procedures.
Interventions
PROCEDUREfertility preservation, several methods
fertility preservation using assisted reproductive techniques or not
Sponsors
Karolinska University Hospital
Karolinska Institutet
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
No minimum to 56 Years
Healthy volunteers
No
Inclusion criteria
* infertile patients and patients who undergo fertility preservation
Exclusion criteria
* Healthy individuals, fertile population
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy and safety of fertility preservation - Long-term follow-up | 2028 | Correlation between method of fertility preservation and pregnacy rate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical outcome of fertility treatments i breast cancer patients | 5-20 years post diagnosis | Fertility treatment vs no fertility treatment i breastcancer patients: effect on survival |
| Predictors of effictive fertility treatment | patient data collected from time of treatment, pregnancy rate until end of study | Correlation between clinical variables (age, BMI, oocyte level, administered gonadotropins, infertility) method of fertility preservation and Pregnancy rate |
| Efficacy and safety of COS using GnRHa for fertility preservation in BC patients | Observed outcomes in patients registered between 1995 and 2017. Follow up until end of 2018. | hCG vs GnRH trigger on effect on number of cryopreserved embryos and oocytes |
Countries
Sweden
Contacts
Primary ContactDan Grandér, Prof
Backup ContactSusanne Gruber
Outcome results
None listed