OCTA Study: Retinal Vascular Changes in Patients With SARS-CoV-2 Infection

Optical Coherence Tomography Angiography in Patients Affected by SARS-CoV-2 Infection: a Pilot Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04601012

Enrollment

Registered

2020-10-23

Start date

2020-09-20

Completion date

2020-10-22

Last updated

2021-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19

Brief summary

This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that have been affected by COVID-19.

Detailed description

To investigate the potential role of optical coherence tomography angiography in identifying the changes in retinal vessel density in patients that have been affected by COVID-19. The optical coherence tomography angiography represents a noninvasive diagnostic technique that allows a detailed analysis of retinal vascular features.

Interventions

DIAGNOSTIC_TESTOptical coherence tomography angiography

Each subject underwent optical coherence tomography angiography to evaluate the retinal vessel density.

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* age older than 18 years * diagnosis of previous COVID-19 * absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * absence of significant lens opacities, low-quality OCT and OCT-A images.

Exclusion criteria

* age younger than 18 years * absence of previous diagnosis of COVID-19 * presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * presence of significant lens opacities, low-quality OCT and OCT-A images.

Design outcomes

Primary

Measure	Time frame	Description
The measurements of retinal features in patients with previous diagnosis of COVID19, using optical coherence tomography angiography.	one month	The parameter analyzed by optical coherence tomography angiography was: retinal vessel density

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026