Pediatric Obesity
Conditions
Keywords
Leptin, Insulin, Sweet Responsiveness, Weight Loss
Brief summary
This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.
Detailed description
Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.
Interventions
DIAGNOSTIC_TESTSerum insulin level
Measure levels before and after weight loss related to bariatric surgery
DIAGNOSTIC_TESTSerum Leptin test
Measure levels before and after weight loss related to lifestyle change weight loss
Sponsors
State University of New York at Buffalo
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Compare the level of insulin, leptin, and sweet taste sensitivity and perception before and after short term weight loss and bariatric surgery
Eligibility
Sex/Gender
ALL
Age
8 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
* Patient of Children's Healthy Weigh of Buffalo * ages of 8-14 If enrolled in the bariatric arm: • must be scheduled for bariatric surgery prior to enrollment
Exclusion criteria
* Patients unable to get labs drawn at a Kaleida facility * Severe hay fever or seasonal allergies within 2 weeks of enrollment * smoker or are exposed to second-hand smoke at home, * has been dieting to lose weight within the past 6 months of enrollment * currently taking any prescription medications that can influence taste or small functions or are pregnant. * pregnancy * Bariatric arm patients will be excluded if they fail to have the surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Higher insulin and leptin levels will be associated with lower sweet taste sensitivity and perception, and higher body fat percentage and z-BMI | to be measured at 6 months | insulin and leptin levels will be measured at various time points in an attempt to identify if there is a change is taste senses associated with specific variables be associated with lower sweet taste |
Outcome results
None listed