Hemodialysis Complication
Conditions
Keywords
hemodialysis, Axl, prognosis
Brief summary
The purpose of this study is to evaluate whether tyrosine kinase receptor Axl affects the dialysis prognosis in chronic hemodialysis patients
Detailed description
It is reported that hemodialysis (HD) patients often develop chronic systemic inflammatoion, and increased inflammatory activity is associated with vascular access failure, cardiovascular disease and death in HD patients. The interaction of Axl and its ligand Gas6 plays an important role in modulating immune response, inhabiting toll-like receptor (TLR) signaling and suppressing inflammatory cytokines production. Thus, we want to investigate the relationship between tyrosine kinase receptor Axl and the dialysis prognosis in HD patients in three-years follow-up.
Interventions
None listed
Sponsors
Ai Peng
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* hemodialysis for more than 6 months
Exclusion criteria
* patients who received warfarin therapy; * patients with chronic infectious disease or acute infection; * patients with hemodialysis inadequacy; * the age of patients is older than 65 years or younger than 18 years. * patients who can not sign an informed consent or disagree to follow up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| death | 3 years | death |
| dialysis complication | 3 years | vascular access failure, stroke, acute coronary syndrome, heart failure |
Countries
China
Outcome results
None listed