Chronic Kidney Disease Requiring Chronic Dialysis
Conditions
Brief summary
Hyperphosphatemia is a common problem among patientens suffering from chronic kidney disease. Hyperphosphatemia is associated with increased risk of cardiovascular diseases. One of the treatments are through the diet, where patients are instructed ind reducing their daily intake of phosphate. But since phosphate exists in both organic and inorganic forms in the diet, this leads to several problems. Informations of the bioavability and furthermore the effect of plasma koncentrations of phosphate are lacking for both forms of phosphate.
Interventions
OTHERDiet containing organic phosphate
The patients will be receiving a 5 days diet containing organic phosphate
OTHERDiet containing inorganic phosphate
The patients will be receiving a 5 days diet containing inorganic phosphate
Sponsors
Stine Kristensen
Gita Krüger Mørch
Rizwan Butt
Ditte Hansen
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \> 18 years * Competent * The patient should be able to take a sample of p-fluid and urine by himself * Chronic peritoneal dialysis * Reads and understand danish * Has been informed written and oraly about the study and signed informed consent * P-phosphate koncentrations 0,7-2,0 .mol/l * P - ioniset calcium 1,1-1,4 mmol/l
Exclusion criteria
* Pregnant or breast-feeding * Terminal patients * If the experience acute infections or other acute situations they will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma levels of phosphate | six days |
Secondary
| Measure | Time frame |
|---|---|
| changes in p-calcium | six days |
| Changes in p-sodium | six days |
| Changes in p-potassium | six days |
| changes in p-PTH | six days |
| Changes in p-phosphate | six days |
| Changes in p-magnesium | six days |
| Koncentration of phosphate in peritoneal dialysis fluid | six days |
| Koncentration of phosphate in urine | six days |
| Changes in p-FGF23 | six days |
Countries
Denmark
Contacts
Primary ContactJens Rikardt Andersen, MD
Backup ContactStine Rikardt Kristensen
Outcome results
None listed