Urine pH and Urinary Tract Infection

Consequences of UTI on Urine pH

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04598971

Acronym

PHURINE

Enrollment

Registered

2020-10-22

Start date

2020-08-01

Completion date

2021-12-13

Last updated

2020-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urinary Stone, Urinary Tract Infections

Keywords

urine pH

Brief summary

Urinary tract infections (UTI) affect the urine pH and may lead to salt precipitation such as struvite. Bacteria with urease activity are known to alkalinise urine, but not much is known on how pH is changing over time during UTI. This study aims at following urine pH progression at the time of diagnosis of UTI and during the treatment phase. Description of the change in urine pH over time will help understanding the risk of struvite formation and potential timing of intervention.

Detailed description

Adults presenting with UTI symptoms will be screened for infection and instructed to monitor urine pH during the course of treatment and 1 week after. Urine pH will be measured by the patients using calibrated pH-stix. Type of bacteria, antibiotics, and the type of diet will be monitored during the study.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

Group 1. Cystitis Inclusion Criteria: * Symptoms of dysuria, pollakiuria, no fever AND * urine-stix positive for leucocytes OR positive culture (\>10E5 cfu/ml) Group 2. Pyelonephritis Inclusion Criteria: * Unilateral flank pain, pollakiuria, dysuria, fever (\>38.5°C) AND * urine-stix positive for leucocytes OR positive culture (\>10E5 cfu/ml)

Exclusion criteria

(both groups): * known urinary tract anatomic abnormalities * Presence of a urine catheter * Sepsis - septic shock * Patient taking drug interfering with urine pH (diuretics, citrate, acetazolamide, topiramate,...) * Patients with UTI diagnosed in the preceding month * Patients having received antibiotics during the preceding month * Male patient with a diagnosis of prostatitis * Presence of infected kidney cyst * Patient with diabetes * Pregnant female * Patient with obstructive pyelonephritis

Design outcomes

Primary

Measure	Time frame	Description
Urine pH	21 days	Urine pH is monitored by the patient every morning during the treatment phase and 7 days after the end of treatment

Countries

Switzerland

Contacts

Primary ContactCharlotte Desponds, BM

Charlotte.Desponds@unil.ch+41795561934

Backup ContactAlexandre Gouveia, MD

Alexandre.Gouveia@unisante.ch

Outcome results