ARDS, Covid19
Conditions
Keywords
lung mechanics, heart-lung interaction
Brief summary
This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies. This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
Interventions
DIAGNOSTIC_TESTAssessment of lung mechanics and heart-lung interactions
Impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry and classic mechanical ventilation parameters
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* SARS-CoV-2 infection * Moderate to Severe ARDS after Berlin Classification at PEEP 5 * Admission to the Institute of Intensive Care of the University Hospital Zurich * Invasive Mechanical Ventilation * Signed Study Informed Consent or emergency procedure according to article 30 HFG
Exclusion criteria
* Pregnant or breast feeding patients * Age \<18 years * Presumed rejection of the study intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time dependent compliance change | Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days) | Compliance change over the length of mechanical ventilation |
| PEEP and time dependent change in dead space | Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days) | Change in Dead Space over the length of mechanical ventilation |
| PEEP and time dependent change in shunt fraction | Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days) | Change in shunt fraction over the length of mechanical ventilation |
Countries
Switzerland
Contacts
Primary ContactPhilipp K Buehler, MD
Outcome results
None listed