Endometrial Injury, Hysteroscopy, Repeated Implantation Failures
Conditions
Keywords
Endometrial injury, Hysteroscopy, RIF, IVF, ART
Brief summary
The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates
Detailed description
After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.
Interventions
PROCEDUREEndometrial injury
Endometrial injury was performed hysteroscopically after freeze all cycles and during the cycle before the frozen embryo transfer
Sponsors
National and Kapodistrian University of Athens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Endometrial injury in RIF patients
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* Women with RIF under 42 years old * BMI 20-30 * Normal endometrial cavity * FSH \<15 IU/L * Absence of immunological or hematological disorder
Exclusion criteria
* women over 42 years old * FSH\>15 IU/L * women with chronic immunological or hematological disorder * stage III or IV of endometriosis * women with pathology concerning the endometrial cavity * women with a medical history of adnexectomy or oophorectomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Physiological parameter - Live birth rate | 22 weeks | The complete expulsion or extraction from a woman of a product of fertilization, after 22 completed weeks of gestational age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physiological parameter -Clinical pregnancy rate | 7 weeks | A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy |
| Adverse event - Miscarriage | 22 weeks | Spontaneous loss of a clinical pregnancy before 22 completed weeks of gestational age |
Countries
Greece
Outcome results
None listed