Sedation and Analgesia
Conditions
Brief summary
This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.
Detailed description
Comparison between using intravenous (IV) propofol combined with either IV dexmedetomidine or IV ketamine or IV midazolam; to study the effect of their combination on level of sedation and hemodynamic stability on adult patients scheduled for gastrointestinal endoscopic procedures.
Interventions
DRUGDexmedetomidine
intravenous dexmedetomidine 1 mic/kg
DRUGKetamine
ketamine 1mg/kg
DRUGMidazolam
midazolam 0.05 mg/kg
Sponsors
National Cancer Institute, Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients scheduled for gastrointestinal endoscopic procedures * ≥ Age 18 years * ASA I-II
Exclusion criteria
* Allergy to any of the used drugs * impaired renal or liver functions * hypertensive patients * patients with cardiovascular * cerebrovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ramsy sedation score (RSS) | 3 to 6 months | time to achievement of Ramsy sedation score (RSS) 3-4, Ramsy sedation scale score from 1 to 6, 1 meaning anxious and 6 meaning no response to stimulus |
Countries
Egypt
Outcome results
None listed