Appetitive Behavior
Conditions
Brief summary
This study examines the effect of soluble fiber dextrin on food intake, appetite, and physiological markers of appetite. Adults aged 18-45 years with a BMI were recruited for this study. Participants were given two doses of SFD in the morning and appetite, food intake and physiological markers of appetite were measured over 10 years.
Detailed description
Overweight and obesity are leading health problems. The study investigates the effect of a food ingredient from two different sources at two different doses on food intake and appetite markers over a 10 hour period. All participants reported to the laboratory first thing in the morning and remained in the laboratory until after their evening meal. A fixed breakfast was served but the participants were free to eat as much as they liked at lunch and dinner. Blood was taken at regular intervals during the day and assayed for glucose and several hormones related to appetite. Subjective measures of appetite were also collected over the 10 hour test session.
Interventions
OTHERSoluble Fiber Dextrin
Ingredient based on resistant starch
Sponsors
Iowa State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Masking description
Material was provided in coded plain packaging. Participants and researchers were unaware of what was being received.
Intervention model description
Human subjects
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
BMI 19.9 - 29.9 Aged 18-45 Find the study foods to be palatable
Exclusion criteria
Weight change \> 3kg in the past three months Do not regularly consume snacks Presence or history of GI disorders Restrained eater Used medication that influences appetite
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Food intake | 10 hours | Food intake measured at lunch and evening meal. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite | 10 hours | Subjective appetite measures using questionnaires at regular intervals over 10 hours, |
| CCK | 10 hours | Plasma CCK measured at regular intervals over 10 hours. |
| GLP-1 | 10 hours | Plasma GLP-1 measured at regular intervals over 10 hours. |
| PYY3-36 | 10 hours | Plasma PYY3-36 measured at regular intervals over 10 hours. |
| Breath Hydrogen | 10 hours | Breath hydrogen measured at regular intervals over 10 hours. |
Outcome results
None listed