Evaluation of Post Infectious Inflammatory Reaction (PIIR) Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection

Evaluation of Post Infectious Inflammatory Reaction (PIIR) in a Retrospective Study Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04594785

Acronym

RIPI

Enrollment

150

Registered

2020-10-20

Start date

2020-10-01

Completion date

2021-12-30

Last updated

2020-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neisseria Meningitides Meningitis, Streptococcus Pneumonia, Streptococcus Pyogenes Infection

Keywords

post-infectious inflammatory reactions, Neisseria Meningitis

Brief summary

As Covid 19 manifestations that have been recently described, inflammatory manifestation have major impact in infectious disease lesions. Some of them are delayed and provide Post infectious inflammatory reaction (PIIR), they are challenging for diagnosis and for management. Clinician have to avoid unnecessary antibiotic thearapy and in if necessary have to give immunosuppressive therapy. Except for rheumatic disease for group A streptococcus (GAS) infections there are not stanrdized diagnostic criteria and therapeutic protocol, and PIIR have probably a suboptimal management. In this context the investigators aim to explore PIIR in the 3 most frequent bacterial invasive infection in France, by a retrospective monocentric study. The investigators include all children betwwen 2012 and 2018 hospitalized for infections by Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), and GAS invasive infections.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

* Less than 18 years of age * Fever associated with GAS, NM, or SP invasive infection

Exclusion criteria

* age \> 18 years * Impossibility to obtain the consent of parents / legal representatives.

Design outcomes

Primary

Measure	Time frame	Description
Describe the frequency PIIRs	1 day	Describe the frequency PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

Secondary

Measure	Time frame	Description
Characteristics PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection	1 day	Describe the characteristics PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

Other

Measure	Time frame	Description
Predictors of PIIRs	1 day	Identified the predictors of PIIRs in order to find warning symptoms

Countries

France

Contacts

Primary ContactEric JEZIORSKI

e-jeziorski@chu-montpellier.fr04 67 33 57 98

Outcome results