Change Trend of Effluent Eosinophil During Peritoneal Dialysis-Related Peritonitis

Study on the Increasing Proportion and Change Trend of Eosinophil in Peritoneal Fluid During Peritoneal Dialysis-Related Peritonitis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04594421

Enrollment

100

Registered

2020-10-20

Start date

2021-02-18

Completion date

2024-04-01

Last updated

2021-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritonitis

Keywords

Peritonitis, eosinophil, peritoneal dialysis

Brief summary

Detailed description

A multi-center prospective cohort study will be conducted to explore the change trend of eosinophil in peritoneal dialysis effluent during peritoneal dialysis-associated peritonitis, and to explore the relationship between eosinophil increase, peritonitis severity and antibiotic use. In this study, 100 patients with peritoneal dialysis-associated peritonitis who meet the inclusion criteria will be selected. Demographic data, laboratory variables, peritoneal fluid cytology and bacterial culture will be collected within 24 hours of peritonitis (day 1). Peritoneal fluid cytology includes leukocyte classification and eosinophilic leukocyte count will be examined at day 3, 5, 7, 10, 14, 21, 30, 60 and 90 after peritonitis. All patients will be followed up for 90 days, and their peritonitis outcome will be recorded. The primary endpoint is the prevalence of eosinophil increase in peritoneal effluent, which is defined as \>100 eosinophils/mm\^3, or \>10% eosinophils of the total non-erythrocyte count. Secondary end points are peritonitis outcome at month 1 and 3 including transfer to hemodialysis , death.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

14 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosed as peritoneal dialysis-related peritonitis; * Age\> 14 years * Maintenance peritoneal dialysis due to end-stage renal failure ≥3 months * Use of lactate glucose dialysate

Exclusion criteria

* Those who cannot be followed up regularly * Reluctant to join this researcher

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of elevated eosinophils in peritoneal dialysis effluent	Feb 18,2021 to December 31,2023	eosinophil number \>100 /mm3, or the proportion of polynuclear leukocytes \>10%.

Countries

China

Contacts

Primary ContactTiantian Ma

matiantian1986@sina.com15201286467

Outcome results