Heart Failure, Ketosis
Conditions
Keywords
Hemodynamics
Brief summary
We aim to investigate the hemodynamic effects of weight-adjusted dosing of ketone monoester en patients with chronic heart failure.
Interventions
DIETARY_SUPPLEMENTKetoneAid KE4 Pro Monoester
A dietary supplement containing ketone monoester.
DIETARY_SUPPLEMENTScience in Sport Go Enegy
Dosis isocaloric to the KetoneAid Arm
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Patients are studied in a randomized single-blind cross-over design.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Chronic HF: NYHA class II-III, left ventricular ejection fraction (LVEF) \<40%
Exclusion criteria
Diabetes or HbA1c \>48 mmol/mol, significant cardiac valve disease, severe stable angina pectoris, severe comorbidity as judged by the investigator, inability to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac Output (L/min) | 3 hours - Area under the curve | Change in Cardiac output measured by Swann-Ganz Catherization during study period, |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Left Ventricular Ejection Fraction | 3 hours - Area under the curve | Change in LVEF measured by echocardiography during study periode |
| Blood Ketones | 3 hours | Change in blood Ketones measured by venous blood samples |
| Blood pH | 3 hours | Change in venous blood pH during the study period |
Countries
Denmark
Contacts
Primary ContactKristian H Christensen, MD
Backup ContactHenrik S Wiggers, DMsci
Outcome results
None listed