Missed Abortion
Conditions
Brief summary
Aim of study Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester?
Detailed description
Aim of the Work Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester? Primary outcome: Complete abortion (complete expulsion of products of conception with no need for curettage) within one week from the first dose of misoprostol. Secondary outcome: • Curettage (surgical evacuation of the products of conception) * Incomplete abortion (retained products of conception). * Considerable bleeding that necessitates immediate evacuation.
Interventions
DEVICELetrozole misoprostol
Letrozole give pretreatment of abortion by misoprostol
DRUGMisoprostol, placebo
Give placebo pretreatment of abortion by misoprostol
Sponsors
Benha University
Dr.Dalia Mohammed Al Sayed Zaki
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Woman age more than 18 years old (age of legal consent). * BMI ranges between 25 kg/m2 and 35 kg/m2. * Gestational age of 63 days' gestation (or less). * Missed abortion. * Hemoglobin leve
Exclusion criteria
* Woman age less than 18 years old. * BMI less than 25 kg/m2 or more than 35 kg/m2. * Gestational age more than 63 days' gestation. * Molar pregnancy. * Hemoglobin level less than 10 gm/dL. * Fibroid uterus. * Uterus with congenital anomalies. * Previous attempts for induction of abortion in the current pregnancy. * Coagulation defect i.e. coagulopathy. * Contraindication for induction of abortion e.g. heart failure. * Allergy to misoprostol or letrozole.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complete abortion | 1week | Complete abortion (complete expulsion of products of conception with no need for curettage) within one week from the first dose of misoprostol. |
Countries
Egypt
Outcome results
None listed