Keratoconus
Conditions
Keywords
Keratoconus, Small Incision, Fresh Lenticule, Stromal Implantation, Stromal Stem Cells, Smile Surgery
Brief summary
CORNEAL LENTICULE IMPLANTATION IN KERATOCONUS DISEASE WITH RELEX SMILE SURGERY
Detailed description
Purpose: The purpose of our study is to investigate the feasibility and effect of fresh lenticule implantation as allogenic graft that will be taken from myopic patients, in order to implant in patients with keratocouns disease using VisuMax Femtosecond laser - Smile module surgery which primary objective in to increase central corneal thickness and secondary objective is to improve visual acuity and reducing K-values. Methods: All the patients were clinically diagnosed with progressive keratoconus. Twenty (20) patients underwent SMILE surgery (first group), and twenty (20) patients underwent lenticule implantation (second group). Visual acuity, corneal topography, electron microscop,anterior segment optical coherence tomography, were analyzed. Outcome: Central corneal thickness were improved at the same day of surgery and vision started to improve at first week postoperatively in the second group (lenticule implant group). Corneal topography showed a statistically significant decrease in the anterior K1 and K2. All the grafts from both groups were clearly visible by anterior segment optical coherence tomography observation and electron microscope. The central corneal thickness was stable during the 6-month study period. No complications were observed during short term follow-up. Opinion: In our opinion, the present study may suggest that this procedure, using fresh lenticule with stromal stem cells and live keratocites is safe, reliable, and effectively increases corneal thickness and improves visual acuity with no adverse effects, which may provide new avenues in the treatment of corneal ectasia. Key Words: keratoconus,small incision,fresh lenticule, stromal implantation,stromal stem cells, Smile surgery
Interventions
PROCEDURELenticule Implantation in Keratoconus Disease with RELEX Smile Surgery
Lenticule Implantation in Keratoconus Disease with RELEX Smile Surgery using VisuMax Femtosecond laser- Smile module surgery with primary objective to increase central corneal thickness and secondary objective to improve visual acuity and reduces K-values
Sponsors
Dr. Faruk Semiz
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
Both models participated in this study. Model ages were from 20 up to 45
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patients clinically diagnosed with progressive keratoconus
Exclusion criteria
* Active anterior segment pathologic features, Corneal thickness over 420, Previous corneal or anterior segment surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Increase of corneal thickness at patients Lenticule group | 12 months | Increase of corneal central thickness using fresh lenticule with stromal stem cells and live keratocytes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of visual acuity at patients Lenticule group | 12 months | Increase of visual acuity using fresh lenticule, decrease of astigmatism and increase of corneal thickness |
Countries
Kosovo
Outcome results
None listed