Movement Disorders
Conditions
Brief summary
Objectives: To generate pilot data to investigate the feasibility and the potential use in clinical practice of technology based objective measures of motor performances in patients affected by different movement disorders. To correlate kinematics findings with demographic and clinical details. Trial design and methods: Participants enrolled in prof. Bhatia's movement disorders clinic, will be classifies according to the main movement disorder, specifically, tremor, parkinsonism, dystonia, chorea, ataxia. In the study visit (one day only), they will undergo a clinical evaluation using the appropriate clinical scales (respectively, Fahn-Tolosa-Marin tremor rating scale, MDS-UPDRS Part III, Toronto Western Spasmodic Torticollis Rating Scale 2, Unified Hungtington Disease Rating scale and Scale for the Assessment and Rating of Ataxia) and a kinematic evaluation, using wearables and an infra-red and LED markers system. Then the protocol is concluded and they will continue the routine clinical follow-up
Interventions
DEVICEkinematic analysis
motor tasks appropriate for each diagnosis will be recorder with wearable inertial sensors
Sponsors
University College, London
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* clinical diagnosis of parkinsonism and/or dystonia and/or tremor due to: 1. idiopatic parkinson's disease 2. atypical parkinsonism 3. sporadic or inherited/genetic dystonia 4. young-onset Parkinson's disease 5. Ataxia syndrome 6. Choereic syndrome 7. Essential tremor 8. Dystonic tremor * 18 to 80 years of age * Willing and able to provide informed consent * able to walk unassisted
Exclusion criteria
* Change in pharmacological therapy in the last 3 months. * Participated in a clinical drug trial up to 3 months before inclusion into the present study * Orthopaedical comorbidities affecting gait or posture. * Cognitive deficit
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gait metrics | up to 6 weeks after enrolment | gait cycles measures (step length, phase duration, number of steps) practice of technology based objective measures of motor performances in patients affected by different movement disorders, to objectively evaluate the disease burden, the efficacy of therapeutic interventions and having a deeper phenotyping of motor disabilities. |
| tremor peak frequence | up to 6 weeks after enrolment | fourier analysis for peak frequence of tremor |
| neck ROM | up to 6 weeks after enrolment | range of motion of the neck in x,y and z axis |
| bradykinesia evaluation | up to 6 weeks after enrolment | amplitude of repeated limb movements over time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| correlation with UPDRS gait Item | up to 6 weeks after enrolment | correlation of gait metrics with UPDRS gait score included. |
Contacts
Primary Contactkailash P Bhatia
Backup Contactgiulia di lazzaro
Outcome results
None listed