Catch me if You Can - the Individual Relationship Between Potential Ablation Targets From CARTOFINDER and Myocardial Fibrosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04586881

Enrollment

Registered

2020-10-14

Start date

2020-10-01

Completion date

2023-03-01

Last updated

2023-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Brief summary

Single center observational study to compare the relationship between atrial fibrosis and potential ablation targets from CARTOFINDER.

Detailed description

A total number of 30 patients will undergo catheter Ablation for persistent AF. Pre-procedural cardiac MRI will be performed with late-gadolinium enhancement to visualize the individual amount and distribution of fibrosis in the right and left atrium. CARTOFINDER-guided mapping will be performed during the ablation procedure followed by AF ablation. The individual relationship between atrial fibrosis and potential ablation targets will be accessed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients undergoing their 1st AF ablation procedure for persistent atrial fibrillation (AF) as per recent Heart Rhythm Society (HRS) consensus document 2. Able to understand and willing to sign the Informed Consent Form. 3. Age ≥18 years.

Exclusion criteria

1. Contraindication for DE-MRI with a full dose of Gadolinium-based contrast agent. 2. Previous left atrial ablation or surgical procedure 3. Renal failure with CrCl \<60 ml/min 4. Women currently pregnant, breastfeeding, or of childbearing age not currently taking or not willing to use a reliable form of contraception 5. Mental or physical inability to take part in the study 6. Uncontrolled hypertension 7. Morbid obesity (BMI \> 35), or inability to be placed in MRI due to body mass.

Design outcomes

Primary

Measure	Time frame	Description
AF recurrence	12 months	recurrence of atrial fibrillation after catheter ablation

Countries

Germany

Outcome results