Spinal Shock
Conditions
Brief summary
the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of IV vasopressor and has low complications and side effects.
Interventions
midodrine group will receive midodrine 10 mg PO q 8 hr with gradual weaning of IV nor-adrenaline after receiving 4 doses of oral midodrine .
DRUGMinirin oral tablet
Minirin group will receive minirin 60 µg PO q 8 hr with gradual weaning of IV nor-adrenaline after receiving 4 doses of oral minirin .
DRUGNor-Adrenaline
control group will receive IV nor-adrenaline and is gradually weaning from it according to routine hospital care without adding oral midodrine or oral minirin .
Sponsors
Ahmed talaat ahmed aly
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age of 18 - 60 years. * Patients of both genders. * Patients diagnosed by spinal shock and they are in the recovery stage .
Exclusion criteria
* Patient refusal. * Anuric or oliguric patients or patients with chronic kidney disease. * Patients with allergy to medication included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| liberation the patient from IV vasopressors with maintaining hemodynamics. | 48 hrs | Blood pressure will be assessed regularly every 15 minutes |
Countries
Egypt
Contacts
Primary ContactAhmed T Ahmed, lecture
Backup ContactAmal A Mohamed
Outcome results
None listed