Cardiovascular Diseases
Conditions
Brief summary
Clinical studies found that poor ST-segment resolution (STR) in electrocardiogram (ECG) occurred in major adverse cardiovascular events (MACE), arrhythmia and heart failure was significantly higher . In clinical work, in patients have poor ST-segment decline, the investigators found by CMR-LGE the corresponding myocardium become thinner and other signs of myocardial scar. The investigators aimed to establish whether poor ST-segment resolution in ECG, as well as CMR-LGE, could detect the presence of myocardial scar in early STEMI patients. In order to provide convenient, cheap and widely used test method for patients who cannot tolerate CMR-LGE. 42 STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured on the baseline and 24 hours after PCI. The study population was divided into two groups by late gadolinium enhanced cardiac magnetic resonance (LGE- CMR), with transmural myocardial scar (\>75%) or non-transmural myocardial scar (\<75%).
Interventions
DIAGNOSTIC_TESTST-segment resolution <40.15%
Forty-two STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured at emergency admission and at 24 h after PCI. Late gadolinium-enhanced cardiac magnetic resonance imaging (CMR-LGE) was performed 7 days after PCI to evaluate myocardial scars.
Sponsors
Chongqing Medical University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Single-branch coronary artery stenosis or occlusion 2. Restoration of coronary perfusion to TIMI flow grade 3 after PCI
Exclusion criteria
1. A prior history of the acute coronary syndrome 2. Coronary revascularization 3. Severe chronic kidney disease 4. Intracardiac pacing leads or other implants precluding CMR-LGE 5. Hemodynamic instability 6. Known claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ST-segment resolution<40.15% | 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed. | CMR-LGE was performed to evaluate myocardial scars. |
| ST-segment resolution>40.15% | 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed. | CMR-LGE was performed to evaluate myocardial scars. |
Countries
China
Outcome results
None listed