ACL, Hyaluronic Acid, PRP
Conditions
Keywords
PRP; ACL reconstruction
Brief summary
Purpose: The purpose of this article is to examine the clinical application of PRP and PRP+hyaluronic acid in disorders in the knee. Methods: The study was conducted on 150 adult patients with age over 20 years old affected by unilateral ACL complete tear and receiving ACL reconstruction. We divided the patients in three groups, and we treated the group A with perioperative injection of HHA, group B with perioperative HHA+PRP, group C with perioperative normal saline. Follow-up: Every 1,3,and 12months, we recheck physical exmianation at OPD and recheck MRI at postoperative 3 months.
Interventions
COMBINATION_PRODUCTRegenLab PRP
PRP preparations also improved functional outcome scores compared to hyaluronic acid and placebo in patients affected by knee osteoarthritis (OA). Based on previous studys, we can conclude that the PRP treatment is a safe and efficacious procedure which can provide functional benefit.
COMBINATION_PRODUCThyaluronic acid
Few studies investigated the effects of HA+PRP combined treatment for knee osteoarthritis (OA). Numerous studies demonstrated the efficacy of HA injection therapy in knee OA for a clinical point of view, reducing the pain and improving the quality of life.
OTHERnormal saline
In this study, we compare introperative PRP/PRP+HA/normal saline in ACL reconstruction patient.
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* receiving unilateral ACL reconstruction in our hospital * postoperative follow-up over 3 month
Exclusion criteria
* postoperative follow-up less than 3 month * possible pregnency * with coagulation disease * NSAIDs intake during study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 150 of participants with preoperative and postoperative Magnetic Resonance Imaging are accessed | postoperative 3 month | anterior cruciate ligament was accessed by MRI T1 and T2 image; MRI was checked by one orthopedist |
| 150 of participants with preoperative and postoperative physical examination are accessed by anterior drawer test and Lachman test | postoperative 1 month | the investigators recheck physical exmianation of participants at OPD; physical examination was checked by one orthopedist |
Countries
Taiwan
Contacts
Primary ContactYi Ping Wei, MD
Outcome results
None listed