Acute Respiratory Distress Syndrome Secondary to Covid-19
Conditions
Brief summary
Study conducted on hospitalized patient in critical ill units in Nancy and Metz to evaluate if early corticosteroid treatment in first seven days after admission improve patients outcome in Acute Respiratory Distress Syndrome secondary to Covid-19 compared to later corticosteroid therapy or no treatment. Also comparison of acquired infection with or without corticosteroid treatment during hospitalisation.
Interventions
DRUGCorticosteroids and Derivatives
Any systemic corticosteroid treatment administrated during ICU stay
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ICU hospitalized with acute respiratory distress syndrome secondary to Sars-Cov-2 infection diagnosed by PCR test * Hospitalized from 01/03/2020 to 30/04/2020
Exclusion criteria
* Mechanical ventilation more than 48 hours at admission * Transfert to another ICU during stay for bed management * Corticosteroid treatment at admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality in ICU | within ICU stay, on average 15 days | Mortality rates in ICU in each group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality d28 | 28 days | mortality at day 28 after ICU admission |
| acquired infections incidence | 28 days | cumulative incidence of infection acquired during ICU stay |
| antibiotics duration | 28 days | number of treatment days with antibiotics during ICU stay |
| mechanical ventilation duration | 28 days | number of days of treatment by mechanical ventilation during ICU stay |
Countries
France
Outcome results
None listed