Cerebral Blood Flow
Conditions
Keywords
Endothelial shear stress, signal-intensity gradient, phase contrast MRI, Time-of-Flight MRI, Carotid Doppler sonography
Brief summary
Cerebral blood flow measurement, which is applied to patients with cerebrovascular-related diseases, provides useful information about hemodynamic status. There was a method using Doppler ultrasound and phase contrast (PC) MRI, but it was not widely used in clinical practice due to limitations in reproducibility between examiners, complexity of procedure, and time-intensive protocol. We intend to measure cerebral blood flow through the signal-intensity gradient (SIG) technique using Time-of-Flight (TOF) of brain magnetic resonance imaging, which can compensate for the shortcomings of the existing research methods. In addition, by analyzing the correlation with the previous methods, Doppler ultrasound and PC MRI, we will evaluate the effectiveness of our new method.
Interventions
DIAGNOSTIC_TESTSignal intensity gradient
Signal intensity gradient: In time-of-flight (TOF) MRA, The signal intensities at the iso-point (Φa; signal intensity at position A \[Xa\] along the arterial contour line) and at the inner point (Φb; signal intensity at position B \[Xb\]) were calculated by using a trilinear interpolation algorithm based on the positions and signal intensities in the eight neighboring voxels. The signal intensities of TOF-MRA were normalized to eliminate the offset and scale effects across the MRA datasets of participants. For each iso-point (position A), the SIG was calculated from the difference in signal intensities between points A and B as follows: Scalar SIG, SI/mm = (Φb - Φa) / │Xb - Xa│ (1) Vector SIG, SI/mm = (Φb - Φa) n / │Xb - Xa│ (2)
Sponsors
Medi Image, Inc
Chonbuk National University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients 18 years of age or older who have been admitted to the neurology department due to a stroke, and those who have already performed brain magnetic resonance imaging 2. Among the patients (1) who underwent carotid artery Doppler ultrasound 3. Patients who fully understand the research objectives and procedures and wish to participate in clinical research voluntarily 4. If a patient is not fully understood due to a decrease in awareness or consciousness, the consent of the legal representative is required
Exclusion criteria
1. Patients whose extracranial artery occlusion or severe stenosis was confirmed in brain magnetic resonance images. 2. Those who judge that the subject is unsuitable for participation in clinical research due to other reasons.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral blood flow correlation | After completion of recruitment, average 1 year | Cerebral blood flow correlation between 3 tests (SIG, PC MR, US) |
Countries
South Korea
Contacts
Primary ContactChan-Hyuk Lee, Prof.
Outcome results
None listed