Caffeine
Conditions
Keywords
CMR, Myocardial oxygenation, Myocardial Function, Coffee
Brief summary
The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation and other cardiovascular magnetic resonance parameters in healthy controls.
Detailed description
Caffeine is presumed to create a confounder with diagnostic imaging. The vasodilatory capacity is considered a key measure for the detection of significant coronary disease with stenosed epicardial arterial conduit vessels and overall microvascular function, including endothelial dysfunction. Twenty nine healthy controls will undergo a baseline cardiovascular magnetic resonance (CMR) exam. Afterwards, participants will consume coffee in the presence of study personnel. This will consist of 3 espresso shots, which will be consumed within 15 minutes. Approximately 2h after coffee consumption the CMR exam will be repeated. The goal will be to investigate the impact of caffeine on myocardial features. In particular the effect on the myocardial oxygenation response to vasodilating and vasoconstricting stimuli.
Interventions
OTHERCaffeine
Consumption of 3 shots of espresso
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Masking description
Blinded image analysis
Intervention model description
Controlled before-after comparison
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Ability to give informed consent, documented by signature * Aged 18 to 45
Exclusion criteria
* MRI Contraindications following current institutional guidelines at the time of the CMR exam * Knowledge or suspicion of pregnancy (verified with a pregnancy test). * Consumption of caffeine 12h prior to the baseline CMR exam (outside of the study protocol). * Known cardiovascular disease, diabetes, severe respiratory disease, obstructive sleep apnea syndrome, chemotherapy and radiation treatment, cerebrovascular and occlusive peripheral vascular disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in myocardial oxygenation responses | Through study completion up to 5 hours, before and after caffeine | Percent (%) Measure of oxygenation-sensitive signal change measured by CMR |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in ejection fraction | Through study completion up to 5 hours, before and after caffeine | Percent (%), measured by CMR |
| Difference in cardiac index | Through study completion up to 5 hours, before and after caffeine | L/min/m2, measured by CMR |
| Difference in myocardial peak strain | Through study completion up to 5 hours, before and after caffeine | Percent (%), a measure of systolic function (shortening and thickening) of the myocardium measured by CMR |
| Difference in myocardial time to peak strain | Through study completion up to 5 hours, before and after caffeine | Milliseconds (ms), measured by CMR |
| Difference in myocardial strain rate | Through study completion up to 5 hours, before and after caffeine | Change in strain over time (/second), measured by CMR |
| Difference in myocardial parametric mapping | Through study completion up to 5 hours, before and after caffeine | Milliseconds (ms), measured by CMR |
| Difference in 4D blood flow | Through study completion up to 5 hours, before and after caffeine | Percent, measured by CMR |
| Difference in rate pressure product | Through study completion up to 5 hours, before and after caffeine | Blood pressure \* heart rate |
Countries
Switzerland
Outcome results
None listed