The Effect of Antiemetics on Bowel Preparation Before Colonoscopy

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04583111

Enrollment

200

Registered

2020-10-12

Start date

2020-03-01

Completion date

2022-03-01

Last updated

2020-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel Preparation

Brief summary

Polyethylene glycol (PEG) is one of the most common laxatives used in colonoscopy. However, 5 - 15% of patients can not complete the preparation due to its poor taste and large volume. So this study is aimed to explore the effect of antiemetics on abdominal discomforts associated with PEG.

Interventions

DRUGDomperidone

Domperidone and sulpiride are antiemetics that may be useful in preventing the PEG-related nausea and vomiting.

DRUGsulpiride

Domperidone and sulpiride are antiemetics that may be useful in preventing the PEG-related nausea and vomiting.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* 18-70 years patients scheduled for colonoscopy

Exclusion criteria

* intestinal obstruction or hemorrhage; * allergy to domperidone, sulpiride or PEG; * pregnancy or breastfeeding; * previous use of prokinetics within 1 month.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of the discomforts during bowel preparation	before colonoscopy	The primary endpoint of this study was the discomforts during bowel preparation such as nausea, vomit, abdominal fullness and pain. These symptoms were assessed as none, mild, moderate and severe. Patients with mild to severe symptoms were classified as presence of discomforts.

Secondary

Measure	Time frame	Description
The quality of bowel preparation assessed by Boston Bowel Preparation Scale	during colonoscopy	The secondary endpoint was the quality of bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS) during the withdrawal phase of colonoscopy. The BBPS uses a 0-3 points scale assessing the bowel preparation quality in 3 segments of the colon (the right, transverse and left colons). BBPS score ≥ 6 were defined as adequate bowel preparation.

Countries

China

Contacts

Primary ContactShengliang Chen, Dr

slchenmd@hotmail.com02158752345

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026