Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients

Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04582279

Enrollment

Registered

2020-10-09

Start date

2020-10-28

Completion date

2026-12-30

Last updated

2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Lung Transplantation Bronchiectasis

Keywords

Post lung transplant, Lung bronchoscopy, Lung biopsy, Lung rejection

Brief summary

This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Detailed description

Lung transplant recipients are at high risk for lung rejection and lung infection after transplant. This is diagnosed by performing lung bronchoscopies and lung biopsies. These procedures carry an increased risk for complications and are costly. This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Interventions

DIAGNOSTIC_TESTLung ultrasound

The lung ultrasound will be performed by a trained pulmonologist by gently pressing a probe to various areas of your chest. This is a non-invasive procedure and you should not feel any pain. The ultrasound will take less than 10 minutes.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Masking description

This study is not blinded

Intervention model description

There is only 1 group of participants being monitored. Every patient will follow the same study procedures

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adult patients (\> 18 yrs) who had undergone single/double/heart-lung transplant * Asymptomatic * Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = \>10% decrease from baseline) * Clear chest radiograph over allograft

Exclusion criteria

* Patients who are unable to consent for the procedure * Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator.

Design outcomes

Primary

Measure	Time frame	Description
Establish predictive value of lung ultrasound	Month 0 to month 12	Determine if lung ultrasound provides the same diagnostic results as bronchoscopy and biopsy

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORTathagat Narula, MD

Mayo Clinic

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026