The Role of OCTA in Patients Affected by Beta Thalassemia

Retinal and Choriocapillaris Vascular Features in Patients With Beta Thalassemia by Means of Optical Coherence Tomography Angiography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04582110

Enrollment

Registered

2020-10-09

Start date

2019-10-01

Completion date

2020-02-28

Last updated

2021-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thalassemia

Brief summary

To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia. Moreover we analyzed the structural retinal parameters (ganglion cell complex and retinal nerve fiber layer), using optical coherence tomography (OCT) in these patients

Detailed description

Beta Thalassemia is one of the most common genetic hemoglobinopathy characterized by a defective β globulin chain synthesis leading to hemolysis and ineffective erythropoiesis. The study investigated the changes in retinal and choriocapillaris vascular features using optical coherence tomography angiography, a novel and noninvasive diagnostic technique that allows a detailed analysis of retinal and choriocapillaris blood flow.

Interventions

DIAGNOSTIC_TESTOptical coherence tomography angiography

Each subject underwent Optical coherence tomography angiography (a non-invasive, fast, diagnostic imaging technique)

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* age older than 35 years * diagnosis of Beta Thalassemia * absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * absence of significant lens opacities, low-quality OCT and OCT-A images.

Exclusion criteria

* age older than 50 years * absence of diagnosis of Beta Thalassemia * presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * presence of significant lens opacities, low-quality OCT and OCT-A images.

Design outcomes

Primary

Measure	Time frame	Description
The measurements of retinal and choriocapillaris features in patients with Beta Thalassemia, using optical coherence tomography angiography.	Four months	The parameters analyzed by optical coherence tomography angiography were: retinal and choriocapillaris vessel density

Secondary

Measure	Time frame	Description
The measurements of retinal structural parameters in patients with Beta Thalassemia, using optical coherence tomography.	Four months	The parameters analyzed by optical coherence tomography were: ganglion cell complex and retinal nerve fiber layer

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026