Morbid Obesity
Conditions
Brief summary
Purpose The aim of this study was to analyze the changes of microbiota among patients undergoing LSG or LRYGB on two levels of gastrointestinal tract (using oral swab and stool sample). We compared samples from patients before and after bariatric operation. Materials and methods This prospective cohort study was conducted in one academic, teaching hospital. The recommendations of the Metabolic and Bariatric Surgery Section of the Polish Surgical Society were used as indication for surgery, that is: Body Mass Index (BMI) ≥35 kg/m2 with obesity-related comorbidities or BMI ≥40 kg/m2. Analysis and endpoints Primary endpoint was to determine the difference in microbiota present in oral cavity and large intestine between patients before and after bariatric surgery. Secondary endpoint was to compare the difference in microbiota changes between patients undergoing LSG and LRYGB
Interventions
PROCEDUREBariatric surgery
Surgical treatment of morbid obesity.
Sponsors
Jagiellonian University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* informed consent to participate in the study * meeting the eligibility criteria for bariatric treatment (either for LSG or LRYGB).
Exclusion criteria
* treatment with antibiotics within 30 days prior to gathering microbiological material * gastrointestinal infections * inflammatory bowel disease * thyroid diseases * cancer (especially the digestive tract) * immunodeficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of microbiota in oral cavity | 6 months |
| Change of microbiota in large intestine | 6 months |
Countries
Poland
Outcome results
None listed