Anesthesia; Reaction, Children, Only
Conditions
Keywords
General anesthesia, Children
Brief summary
General anesthesia induces hemodynamic changes, notably a reduction of arterial blood pressure going up to 30%, that may impact cerebral perfusion and oxygenation.The purpose of this study is to assess the impact of anesthesia on the cerebral oxygenation, the perfusion of the brain (assessed with transcranial doppler), and the depth of anesthesia in children between 6 months and 5 years old during the induction of general anesthesia (induced with sevoflurane and/or IV agents). It is expected that the cerebral hemodynamic will be maintained despite systemic variations.
Interventions
PROCEDUREGeneral anesthesia
Children under general anesthesia for an elective surgery, aged between 6 months and 5 years old, ASA 1-2.
Sponsors
St. Justine's Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Months to 5 Years
Healthy volunteers
No
Inclusion criteria
* General anesthesia for elective surgery * American Society of Anesthesiologists score 1 and 2 * Written informed consent obtained from the parents or legal tutors.
Exclusion criteria
* 3 unsuccessful attempts of IV access * ultrasound device non available * neurologic comorbidity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in NIRS values during induction | baseline and 1 minute after intubation | Changes in cerebral Near infra-red spectrometry values |
| Changes in cerebral velocity of the middle cerebral artery during induction | baseline and 1 minute after intubation | — |
| Changes of Response Entropy (RE) value during induction | baseline and 1 minute after intubation | — |
| Changes of State Entropy (SE) value during induction | baseline and 1 minute after intubation | Depth of anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Endtidal Co2 after induction | 1 minute after intubation |
| Changes in NIRS values after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |
| Changes of State Entropy (SE) value after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |
| Change in cerebral velocity of the middle cerebral artery after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |
| Changes of arterial blood pressure during induction | At baseline and 1 minute after intubation |
| Changes of Response Entropy (RE) values after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |
Countries
Canada
Outcome results
None listed