Prehabilitation in Esophageal Cancer Care

Prehabilitation to Enhance Functional Capacity in Esophageal Cancer Care

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04581005

Enrollment

Registered

2020-10-09

Start date

2019-08-19

Completion date

2022-11-30

Last updated

2021-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal Cancer

Brief summary

Prehabilitation utilizes the preoperative period to prevent or attenuate the treatment-related functional decline and its consequences. This project aims at testing feasibility and effectiveness of multimodal prehabilitation in esophageal cancer care.

Detailed description

While evidence on prehabilitation is mounting, upper gastrointestinal surgery still remains under-investigated. This trial aims to explore the effect of prehabilitation over the whole perioperative trajectory, including neo-adjuvant treatment (NAT). Multimodal prehabilitation includes exercise, nutrition therapy, and mental distress coping strategies. In the context of a multimodal approach, the two groups follow different exercise prescriptions: high-intensity interval supervised training prescribed accordingly cardiopulmonary exercise testing (CPET)-derived variables, versus a home-based program. For both groups, multimodal prehabilitation is prescribed over the whole preoperative period, including during NAT.

Interventions

BEHAVIORALPrehabilitation

Endurance and Resistance Exercise, Nutrition therapy, reducing intervention during the whole preoperative period

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with non-metastatic esophageal cancer undergoing neo-adjuvant chemotherapy and surgery.

Exclusion criteria

* co-morbid medical, physical and mental conditions that contraindicate exercise or oral nutrition

Design outcomes

Primary

Measure	Time frame	Description
Oxygen consumption (VO2)	Change from baseline to 2 months after surgery	Oxygen consumption at anaerobic threshold (VO2 at AT) measured with cardiopulmonary exercise testing (CPET)

Countries

Canada

Contacts

Primary ContactFrancesco Carli, MD MPhil

franco.carli@mcgill.ca514-934-1934

Backup ContactEnrico M Minnella, MD PhD

enrico.minnella@mail.mcgill.ca514-934-1934

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026