Heart and Kidney Ketones Metabolism

Exogenous Ketone Salt on Heart and Kidney Ketone Metabolism Measured by Positron Emission Tomography

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04580823

Enrollment

Registered

2020-10-08

Start date

2020-10-15

Completion date

2023-01-15

Last updated

2023-07-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

Participants will undergo 3 Positron Emission Tomography (PET) scans in 3 different conditions : 1. Fasting without exogenous ketone salt 2. Fasting with exogenous ketone salt supplement 3. Post-Prandial with exogenous ketone salt supplement.

Detailed description

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt with or without food intake in middle-aged adults. Participants will have 3 different PET scan to perform : 1. Fasting without exogenous ketone salt 2. Fasting with exogenous ketone salt supplement 3. Post-Prandial with exogenous ketone salt supplement.

Interventions

DIETARY_SUPPLEMENTFasting with exogenous ketone salt supplement

Participants will have to take 2 doses of supplement, one 75 minutes before the scan and one 30 minutes before the scan.

DIETARY_SUPPLEMENTPost-Prandial with exogenous ketone salt supplement

Participants will have to take 2 doses of supplement, one 75 minutes before the scan and one 30 minutes before the scan and they will have a liquid meal 20 minutes before the scan.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Intervention model description

Each participant will have to do the 3 acute interventions

Eligibility

Sex/Gender

ALL

Age

45 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged between 45 and 64 * Generally Healthy * BMI between 18.5 and 27

Exclusion criteria

* All drugs taken on a daily basis * Diabetes or pre-diabetes * Digestive dysfunction * Pregnancy or lactation * Allergy to the supplement * Participate in an intensive physical exercise training (more than three times a week) * Being on a ketogenic diet or consumption of ketogenic supplement. * More than 2 alcoholic beverages each day * Any clinically significant anomaly in the blood profile * Smoking * Claustrophobia * Being enrolled in another interventional research project or in a PET research project * Unable to lie dorsally supine for at least 60 minutes

Design outcomes

Primary

Measure	Time frame	Description
11C-Acetoacetate Heart Ketone uptake	60 minutes	Heart ketone uptake measured by PET scan
11C-Acetoacetate Kidney ketone uptake	60 minutes	Kidney ketone uptake measured by PET scan
Cardiac Functions, telediastolic volume	60 minutes	telediastolic volume
Cardiac Functions, telesystolic volume	60 minutes	telesystolic volume
Cardiac functions, ejection fraction	60minutes	Ejection fraction

Secondary

Measure	Time frame	Description
Plasma ketone	60 minutes	Plasma ketone concentration

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026