Hypotension
Conditions
Brief summary
the study is designed to compare the effect of addition of oral Ivabradine, propranolol to general anesthesia aimed reduction in blood loss during functional endoscopic sinus surgery.
Interventions
DRUGoral Ivabradine
Ivabradine group will receive ivabradine 5mg PO in the evening and 1 hour before anesthetic induction
DRUGoral Propranolol
propranolol group will receive propranolol 10 mg PO in the evening and 1 hour before anesthetic induction.
Sponsors
Ahmed talaat ahmed aly
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age of 18 - 60 years. * Patients of both genders. * ASA grade I - II .
Exclusion criteria
* Patient refusal. * Any contraindication to medication included in the study . * Patients with allergy to medication included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in blood loss | immediately after the surgery | Estimated blood loss in millilitres per hour is calculated by subtracting the volume of total irrigation used during the case from the total amount of fluid in the suction canister at the end of surgery in addition, pre-weighing and post-weighing of sponges and oropharyngeal packs were also done and dividing by surgical time in hours. assessment of blood loss by Boezaart and van der Merwe Grading System for bleeding during Endoscopic Sinus Surgery |
Countries
Egypt
Contacts
Primary ContactAhmed T Ahmed, A professor
Backup ContactAmal A Mohamed
Outcome results
None listed