HIV Infections
Conditions
Brief summary
HIV-infected patients with intermediate-high risk have a high prevalence of CAD and a substantial proportion of obstructive CAD. Degree of stenosis is associated with immunoactivation (lymphocyte and monocyte) and microbial translocation
Interventions
OTHERcoronary computed tomographic angiographic (CCTA)
x-ray examination with contrast by a 64-slice CT coronary angiography.
Sponsors
Hôpital Européen Marseille
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
HIV-infected patients \>= 45 years with 2 or more CV risk factors currently on ART HIV-RNA \< 50 copies \>= 12 months (one blip allowed) Asymptomatic regarding cardiac symptoms (chest pain, syncope, dyspnea) Stable ART for more than 6 months
Exclusion criteria
* Sign of coronary pathology (chest pain, syncope, dyspnea). * ATCD of allergy to IV contrast agents * Chronic inflammatory disease other than HIV * Subject to a measure for the protection of justice
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| correlation between a particular profile of immune activation in patients HIV under treatment presenting cardiovascular risk factors and the presence of coronary atheromatous plaques | 24 months | Assessment of the prevalence of obstructive coronary artery disease in patients infected with HIV and asymptomatic with a 64-slice CT coronary angiography. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identify the bacterial populations constituting the intestinal microbiota in patients infected with HIV and look for a microbiotic signature in patients with subclinical atherothrombosis. | 24 months | microbial translocation (16S DNA) |
Countries
France
Outcome results
None listed