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Prevalence and Risk Factors for the Carriage of Bacteria and Clostridioid in Elderly Dependent Persons

Prevalence and Risk Factors for the Carriage of Multi- and Highly Resistant Bacteria and Clostridioid Difficile Toxigenic in Residents and Healthcare Workers in Nursing Home (PREMS)

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04579094
Acronym
PREMS
Enrollment
492
Registered
2020-10-08
Start date
2022-05-25
Completion date
2024-09-30
Last updated
2025-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly, Healthcare Associated Infection

Brief summary

Brief summary : Very few studies have evaluated the prevalence of multi-drug resistant (MDR), highly resistant emerging bacteria and Clostridioides difficile toxinogenic (CDt) in residents and in healthcare workers (HCW) in nursing home (NH). Most of study were conducted in acute care services and were limited to specific bacterial species. Hypothesis : The carriage of MDR bacteria in resident may be a risk factor for an outbreak in NH or in healthcare facility. Primary outcome: The objective of this study is to estimate the prevalence for carriage of MDR bacteria and CDt in residents in NH. Secondary outcomes: * Estimate the prevalence for carriage of MDR bacteria and CDt toxigenic in HCW in NH. * Identify the risk factors for carriage of MDR bacteria and CDt in residents in nursing home * Identify the risk factors for carriage of MDR bacteria and CDt in healthcare workers in NH * Evaluate the presence of cross-transmission of MDR bacteria and CDt in one or several NH * Evaluate the association between the presence of cross-transmission of MDR bacteria and CDt in a NH and the management of infection control * Establishment a collection of stool samples

Interventions

OTHERFeces sampling at inclusion (J0)

Feces sampling at inclusion (J0)

Sponsors

Centre Hospitalier Universitaire de Nīmes
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Inclusion criteria: * Resident : The resident must be a member or beneficiary of a health insurance. The resident is in permanent accommodation whose the date of admission is at least 1 month earlier on the day of collection. * healthcare workers : The healthcare workers must be a member or beneficiary of a health insurance. The healthcare workers begin to work in nursing at least 1 month earlier on the day of collection. *

Exclusion criteria

* Resident : The resident refuses to participate. o healthcare workers : The healthcare workers refuses to participate.

Design outcomes

Primary

MeasureTime frameDescription
Presence or absence of multi-drug resistant bacteria in residents' feces.at inclusion (J0)prevalence of carriage of multi-drug resistant bacteria
Presence or absence of Highly Resistant and Emerging Bacteria in residents' feces.at inclusion (J0)prevalence of carriage of Highly Resistant and Emerging Bacteria
Presence or absence of Clostridioids difficult toxinogenic in residents' feces.at inclusion (J0)prevalence of carriage of Clostridioids difficult toxinogenic

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026